St Jude Childrens Research Hospital

Phase 1 dose-escalation clinical trial to determine the phase 2 dose of autologous TIL 1383I TCR gene-modified T cells using a retrovirus for patients with advanced melanoma.

The Leukemia & Lymphoma Society awarded $13.8 million in new pediatric research grants designed to identify more effective and precise treatments for children with blood cancer.

As researchers work to expand curable approaches for sickle cell disease, new options for managing its acute and chronic complications appear within reach.

CHICAGO — The Conquer Cancer Foundation of ASCO presented ASCO Annual Meeting Merit Awards to more than 100 oncology professionals.

CHICAGO — Venetoclax in combination with cytarabine alone or with idarubicin demonstrated clinical activity and appeared safe among children with relapsed or refractory acute myeloid leukemia, according to results of a phase 1 study presented at ASCO Annual Meeting.

Children with central nervous system or other solid tumors with specific gene fusions responded to treatment with the investigational tyrosine kinase inhibitor entrectinib, according to results of a phase 1/1b trial scheduled for presentation at ASCO Annual Meeting.

Researchers at St. Jude Children’s Research Hospital identified eight new subtypes of B-cell acute lymphoblastic leukemia, an advance that they hope could lead to improved diagnosis and treatment of high-risk children and adults.

Infants with newly diagnosed X-linked severe combined immunodeficiency, or SCID-X1, demonstrated multilineage engraftment of transduced cells after receiving lentiviral vector gene therapy and nonmyeloablative targeted busulfan conditioning, according to study findings published in The New England Journal of Medicine.

ATLANTA — A research team at St. Jude Children’s Research Hospital has identified a single nucleotide polymorphism that may increase risk for stroke among childhood cancer survivors treated with cranial radiation therapy, according to a report from the St. Jude Cohort Lifetime study presented at the American Association for Cancer Research Annual Meeting.

FORT WORTH, Texas — Self-care is critically important for health care providers to avoid compassion fatigue and prevent burnout, according to a presenter at HOPA Ahead 2019.