St Jude Childrens Research Hospital
Targeted therapy provides ‘phenomenal’ benefit for certain children with glioma
CHICAGO — A combination of two targeted therapies significantly improved outcomes compared with standard care for children with BRAF V600 mutation-positive low-grade glioma, according to study results presented at ASCO Annual Meeting.
Genetic ancestry associated with molecular subtypes, prognosis of childhood ALL
Acute lymphoblastic leukemia molecular subtypes and prognosis appeared associated with genetic ancestry, suggesting a possible genetic basis for racial and ethnic disparities in ALL, according to a study in JAMA Oncology.
Addition of anti-GD2 antibody to chemotherapy improves outcomes in high-risk neuroblastoma
The addition of the novel monoclonal antibody hu14.18K322A to induction chemotherapy significantly improved outcomes among children with newly diagnosed high-risk neuroblastoma, according to phase 2 study results.
Researchers uncover new subtype of pediatric AML defined by UBTF tandem duplications
Upstream binding transcription factor tandem duplications, or UBTF-TDs, identified through integrated genomic analysis represent a new subtype of acute myeloid leukemia that previously had no known oncogenic driver, study results showed.
Personal experiences with cancer help clinicians ‘share the journey’ with patients
Christian S. Hinrichs, MD, is reluctant to give cancer credit for anything good.
Children with cancer more likely to have severe COVID-19 illness
Children with cancer who contracted COVID-19 developed more serious infections and had a greater likelihood of hospitalization or death than the general pediatric population, according to study results published in The Lancet Oncology.
Early intervention key to mitigate neurocognitive effects of pediatric cancer treatment
As cancer treatment options continue to improve, the growing number of childhood cancer survivors will require individualized strategies and risk assessment to help prevent and monitor neurocognitive late effects.
Frailty associated with neurocognitive decline among young-adult cancer survivors
Treatment-associated frailty appeared associated with neurocognitive declines among a cohort of young-adult cancer survivors, according to study findings from the St. Jude Lifetime Cohort published in Journal of Clinical Oncology.
Oncologist urges peers to share their stories of gender discrimination, harassment
As physicians and leaders in health care continue to work toward gender equity in a system that often allows harassment to go unchecked, Erica C. Kaye, MD, MPH, issued a call to action for individuals to share their unheard stories.
Young children with brain tumors may experience cognitive difficulty before treatment
Young children with brain tumors experienced cognitive difficulties prior to adjuvant treatment, with those of a younger age at diagnosis and lower socioeconomic status at greatest risk, according to a study in Journal of Clinical Oncology.