Schizophrenia

Olanzapine/samidorphan combination treatment reduced weight gain across several subgroups of individuals at increased risk for weight gain with olanzapine, according to results of a subgroup analysis.

While the prevalence of chronic kidney disease is higher in patients with severe mental illness compared with the general population, limited research has made it difficult for staff to detect key markers of mental illness, a speaker said.

Adults with severe mental illness and diabetes need more intensive interventions and greater support to overcome barriers to diabetes self-management, according to a study published in Diabetic Medicine.

Lower brain glutamate levels were linked to antipsychotic exposure rather than to greater age-related decline in people with schizophrenia, according to results of a mega-analysis published in JAMA Psychiatry.

Long-acting injectable antipsychotics provided significant benefit in prevention of hospitalization or relapse for schizophrenia compared with oral antipsychotics, according to study results published in The Lancet Psychiatry.

Patients with a severe mental illness had increased risk for mortality after MI compared with those without a diagnosis of mental illness, according to results published in BMC Medicine.

Individuals with schizophrenia and co-morbid insomnia were at increased risk for suicidal ideation, recent suicide attempt and greater psychopathology, according to study results published in Journal of Clinical Psychiatry.

Older adults with schizophrenia had an increased risk for a dementia diagnosis, according to results of a retrospective cohort study published in JAMA Psychiatry. 

Lower angiotensin-converting enzyme messenger RNA and protein levels were associated with increased schizophrenia risk, according to results of a Mendelian randomization study published in JAMA Psychiatry.

Individuals with mental disorders were at increased risk for suicide, according to results of a systematic review and meta-regression analysis published in Journal of Psychiatric Research.