Schizophrenia

A novel glycine transporter inhibitor improved cognition after 12 weeks among individuals with schizophrenia, according to results of a double-blind, randomized, placebo-controlled phase 2 study published in The Lancet Psychiatry.

The presence of metabolic disorders appeared significantly linked to cognitive deficits among individuals with schizophrenia, according to results of a systematic review and meta-analysis published in JAMA Psychiatry.

Long-acting injectable formulations of paliperidone, aripiprazole and olanzapine had the highest effect sizes and certainty of evidence for relapse prevention and acceptability, researchers noted in American Journal of Psychiatry.

Baseline variables not routinely assessed and targeted by intervention programs in community mental health services were linked to functional outcomes at follow-up for schizophrenia, according to study results published in JAMA Psychiatry.

Schizophrenia spectrum disorder diagnosis appeared to be a significant risk factor for mortality among individuals with COVID-19, according to results of a retrospective cohort study published in JAMA Psychiatry.

Clozapine appeared to be the optimal treatment for violent schizophrenia patients with conduct disorder, according to study results published in American Journal of Psychiatry.

Schizophrenia spectrum disorder was linked to an increased risk for Parkinson’s disease later in life, according to study results published in Movement Disorders.

Long-acting injectable paliperidone use was associated with significant improvement in clinical and functional outcomes among individuals with schizophrenia, according to study results published in Journal of Clinical Psychiatry.

Physical activity did not appear to have preventive effects for schizophrenia, according to results of a two-sample mendelian randomization analysis published in JAMA Psychiatry.

An asenapine transdermal system appeared effective for treating schizophrenia, according to results of a phase 3, randomized, placebo-controlled study published in Journal of Clinical Psychiatry.