Osteoporosis

Although causality is difficult to prove definitively, mounting evidence suggests adverse health consequences of endocrine-disrupting among humans. Recent research links these ubiquitous compounds to pediatric obesity, diabetes, osteoporosis and more.

A cross-sectional analysis of more than 1,400 men suggested that phthalate metabolites from plastics and personal care products influenced testosterone levels — a top story in endocrinology last week.

Combining indices of frailty and trabecular bone score did not yield improved predictive accuracy for major osteoporotic fracture risk when compared with frailty alone or trabecular bone score alone, according to findings published in the Journal of Bone and Mineral Research.

Larger mid-arm muscle circumference is associated with lower risk for osteoporosis among men, according to findings published in the Archives of Gerontology and Geriatrics.

Postmenopausal women with osteoporosis who received a single infusion of zoledronate after 2 to 5 years of denosumab therapy retained more than half of bone mineral density gained before stopping treatment with no increase in vertebral fractures, according to findings published in the Journal of Bone and Mineral Research.

Adults with pheochromocytoma or paraganglioma are nearly five times more likely to experience a vertebral fracture, a hallmark of osteoporosis, when compared with adults with nonfunctional adrenal tumors, according to findings published in Bone.

Women who experience a first fragility fracture are at significant risk for experiencing subsequent fractures, particularly in the 2 years after the fracture, according to findings published in the Journal of Bone and Mineral Research.

A cohort of children presenting with increased bone fragility and no extraskeletal signs of osteogenesis imperfecta tended to have a collection of common gene variants that predispose to osteoporotic fracture rather than a monogenic etiology of their condition, according to findings published in the Journal of Bone and Mineral Research.

A longer interval between denosumab injections is associated with suboptimal bone mineral density response at the spine and total hip, and strategies to improve the timely administration of denosumab in real-world settings are needed, according to findings published in The Journal of Clinical Endocrinology & Metabolism.

Men with type 2 diabetes are more likely to develop osteoporosis if they have elevated follicle-stimulating hormone, or FSH, whereas elevated estradiol is associated with lower osteoporosis risk, according to findings published in the Journal of Diabetes.