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Massachusetts General Hospital

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June 12, 2023
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First- vs. second-line CDK4/6 inhibitor use fails to benefit breast cancer subgroup

First- vs. second-line CDK4/6 inhibitor use fails to benefit breast cancer subgroup

CHICAGO — First-line use of cyclin-dependent kinase 4/6 inhibitors did not confer significant benefit vs. second-line use when added to endocrine therapy for women with hormone receptor-positive, HER2-negative, advanced breast cancer.

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June 06, 2023
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Tumor-treating fields extend OS in metastatic NSCLC

Tumor-treating fields extend OS in metastatic NSCLC

CHICAGO — The addition of tumor-treating fields to second-line therapy prolonged survival for patients with metastatic non-small cell lung cancer whose disease progressed on or after platinum therapy, according to results presented at ASCO Annual Meeting.

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May 30, 2023
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SOLVE-CRT: Leadless pacemaker can deliver CRT to people not suited for traditional systems

SOLVE-CRT: Leadless pacemaker can deliver CRT to people not suited for traditional systems

A leadless, ultrasound-based endocardial pacing system was able to deliver cardiac resynchronization therapy to patients unable to be implanted with conventional CRT devices, researchers reported.

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May 25, 2023
11 min read
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Efforts to improve oral chemotherapy adherence target multilevel barriers

Efforts to improve oral chemotherapy adherence target multilevel barriers

Development and use of oral chemotherapy medications has increased substantially over the past decade, offering many patients with cancer a more convenient and less stressful treatment option.

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May 22, 2023
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Bladder cancer therapy with BCG vaccine may reduce risk for Alzheimer’s, related dementias

Bladder cancer therapy with BCG vaccine may reduce risk for Alzheimer’s, related dementias

The BCG vaccine appeared associated with a significantly lower rate of and risk for Alzheimer’s disease and related dementias among patients with nonmuscle-invasive bladder cancer, according to data published in JAMA Network Open.

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April 20, 2023
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Sleeve gastrectomy linked to bone strength, BMD decline among adolescents and young adults

Sleeve gastrectomy linked to bone strength, BMD decline among adolescents and young adults

Adolescents and young adults with obesity who undergo sleeve gastrectomy have declines in bone strength and volumetric bone mineral density 1 year after surgery, according to study data.

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April 04, 2023
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CAR T cells improve quality of life for majority of recipients

CAR T cells improve quality of life for majority of recipients

Patients with hematologic malignancies reported significant improvement in quality of life after receiving chimeric antigen receptor T cells, results from a longitudinal study in Blood Advances showed.

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April 03, 2023
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Earlier age at menopause, later HT initiation linked to Alzheimer’s disease vulnerability

Earlier age at menopause, later HT initiation linked to Alzheimer’s disease vulnerability

Being younger at menopause onset and initiating hormone therapy after more than 5 years were both linked to increased tau vulnerability among women, according to a cross-sectional study published in JAMA Neurology.

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March 29, 2023
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Infants exposed to COVID-19 in utero gain more weight during first year of life

Infants exposed to COVID-19 in utero gain more weight during first year of life

Mothers who contract COVID-19 during pregnancy are more likely to have infants with a lower birth weight and greater weight gain during the first year of life compared with mothers who did not have COVID-19, according to study data.

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March 24, 2023
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VIDEO: Robotic assistance may be warranted for complex adult spinal deformity surgery

VIDEO: Robotic assistance may be warranted for complex adult spinal deformity surgery

LAS VEGAS — In this video from the American Academy of Orthopaedic Surgeons Annual Meeting, Andrew J. Schoenfeld, MD, discussed the cost-utility benefits of robotic assistance for adult spinal deformity procedures.

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