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Leptin

Clinical Guidance
Obesity
Overview

The Pathophysiology of Obesity

Caroline M. Apovian, MD, FACP, FTOS, DABOM; Louis J. Aronne, MD, FACP; Sarah Barenbaum, MD

Free clinical reference tool that includes treatment options; diagnosis information; guidelines; and more.

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January 03, 2023
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Women who eat more ultraprocessed foods more likely to have leptin resistance

Women who eat more ultraprocessed foods more likely to have leptin resistance

Women who eat more ultraprocessed foods are more likely to have leptin resistance and may have alterations in their gut microbiota, according to a study published in Nutrition, Metabolism & Cardiovascular Diseases.

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June 11, 2022
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Lower tibial cortical BMD, bone strength observed in male runners vs. nonathletes

Lower tibial cortical BMD, bone strength observed in male runners vs. nonathletes

ATLANTA — Male runners are more likely to have lower tibial bone mineral density and strength compared with nonathletes, according to a presenter at ENDO 2022.

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January 31, 2022
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Link between leptin, type 2 diabetes risk differs by gestational diabetes history

Link between leptin, type 2 diabetes risk differs by gestational diabetes history

Four body fat-related biomarkers are linked to risk for type 2 diabetes for parous women; for one of these, the association differs by gestational diabetes status, researchers found.

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December 07, 2020
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NHANES: High leptin levels independently associated with low testosterone in men

NHANES: High leptin levels independently associated with low testosterone in men

Increasing leptin levels are independently associated with decreasing testosterone and could be a cause for testosterone deficiency in men with obesity, according to data from the National Health and Nutrition Examination Survey III.

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November 10, 2020
3 min read
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Old genetic discoveries may reveal ‘new tricks’ for treating obesity

Old genetic discoveries may reveal ‘new tricks’ for treating obesity

Genetic modifiers — many discovered in the late 1990s — can be “harnessed” to better understand the processes and mechanisms behind weight gain and one day even regulate appetite, according to a speaker.

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December 16, 2019
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Preconception leptin level predicts risk for adverse pregnancy outcomes

Preconception leptin level predicts risk for adverse pregnancy outcomes

Healthy women with a high preconception leptin level are nearly 20 times more likely to develop gestational diabetes when compared with women with a low leptin level, although leptin was not shown to influence risks for pregnancy loss or preterm delivery, according to findings published in Obesity Science & Practice.

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September 05, 2019
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High preconception leptin level may decrease probability of pregnancy

High preconception leptin level may decrease probability of pregnancy

Among women with a history of prior pregnancy loss, higher levels of preconception leptin are associated with decreased fecundability and reduced likelihood of pregnancy and live birth, according to findings published in the Journal of the Endocrine Society.