Immunosuppression
Ceasing both immunosuppressants, glucocorticoids leads to IgG4-RD relapse in most patients
SAN DIEGO — Maintaining immunosuppression with or without low-dose glucocorticoids is superior to withdrawing both therapies in preventing relapses in IgG4-related disease, according to data presented at ACR Convergence 2023.
Steroid, rituximab use can lead to secondary immunodeficiencies
ANAHEIM, Calif. — Use of steroids and B-cell depleting therapies may lead to secondary immunodeficiencies, according to a presentation at the American College of Allergy, Asthma & Immunology Annual Scientific Meeting.
AX-158 receives clinical trial authorization for phase 2a psoriasis study in UK
AX-158 has received clinical trial authorization from the United Kingdom’s Medicines and Healthcare Products Regulatory Agency for a phase 2a psoriasis study, Artax Biopharma announced in a press release.
People with HIV, mpox not at increased risk for hospitalization unless immunosuppressed
People with HIV diagnosed with mpox were not at an increased risk for hospitalization unless they were immunosuppressed, according to findings presented at the International AIDS Society Conference on HIV Science.
Researchers successfully transplant stem cells to protect donor kidney
Researchers at Stanford Medicine showed that a stem cell transplant from a living-related kidney donor before the recipient received the transplant from the same donor eliminated the need for use of immunosuppressive drugs long term.
Pre-transplant immunosuppression for glomerulonephritis linked with greater cancer risk
Using pre-transplant immunosuppression to treat kidney transplant recipients with glomerulonephritis correlates with an increased risk for developing malignancy after transplant, according to a retrospective study.
Immunosuppression not a risk factor for poor outcomes in cutaneous squamous cell carcinoma
Immunosuppression is not an independent risk factor for poor outcomes in patients with cutaneous squamous cell carcinomas when adjusting for tumor stage, according to a study.
Patients with IgA vasculitis nephritis achieved remission using immunosuppression therapy
Pediatric patients with IgA vasculitis nephritis and nephrotic-range proteinuria achieved remission after 12 months of mycophenolate mofetil-based immunosuppression treatment, according to data published in Kidney Medicine.
Kidney transplant recipients may have immune-insufficiency during acute COVID-19
Kidney transplant recipients experience immune-insufficiency during acute COVID-19, which may explain the low rates of acute rejection among these patients even with reduced immunosuppression, according to a recently published study.
Immunosuppression may benefit long term in virus-negative inflammatory cardiomyopathy
Immunosuppressive therapy for virus-negative inflammatory cardiomyopathy was associated with reduced CV mortality and need for transplantation and persistent improvements in left ventricular function, researchers reported.