Hormone Therapy
Reproductive concerns among transgender adolescents may manifest as ‘disinterest’ in future parenthood

A small cohort of adolescents and young adults who identify as transgender reported limited baseline knowledge of reproduction and expressed underlying reproductive concerns that may manifest as disinterest in becoming a parent, according to findings from a pilot study published in Transgender Health.
State-level nondiscrimination policies may decrease suicidality among gender minority individuals
More depression reported by women with premature menopause, current HT use
Gender-affirming HT poses no hypertension risk

Among a large cohort of transgender adults prescribed gender-affirming hormones, higher levels of cross-sex hormones did not increase the odds of hypertension, and hypertension diagnoses were fewer among transgender women who were ever prescribed progestins, according to data published in Transgender Health.
'More hopeful outcomes' on the horizon for Prader-Willi syndrome

Prader-Willi syndrome, a neurodevelopmental disorder that occurs in about 1 in 15,000 births, is the most common genetic cause of life-threatening childhood obesity, which is just one of its complex symptoms. Still, it has proved extremely difficult to treat. Fortunately for the Prader-Willi syndrome community, researchers continue to test potential therapies to find a comprehensive treatment or a way to curb the most severe symptoms.
Researchers explore cognitive effects of hormone therapy for prostate cancer
Depression, suicidal ideation rates high among transgender teens

Many adolescents who identify as transgender or gender nonconforming were identified as experiencing psychological comorbidities, such as depression, anxiety and suicidal ideation, with a greater burden observed among transgender males vs. transgender females, according to findings accepted for presentation at the Endocrine Society Annual Meeting.
Subsequent PFS benefit of apalutamide ‘an indicator of effective early intensive treatment’ in prostate cancer
Controversial pubertal blocker legislation may bring unintended consequences for children

Several states across the country have introduced or are considering legislation that would prohibit medical treatment for children who may be transgender, including the use of pubertal blockers, a trend that has alarmed clinicians who say such bills reflect widespread misunderstandings and go against evidence-based practices.
Hypothyroidism, HT exert opposite risks for postmenopausal breast cancer

In a large prospective cohort of postmenopausal women, those who had ever had hypothyroidism — whether treated with levothyroxine or not — were less likely to develop breast cancer than those without hypothyroidism, and the relationship was more pronounced among those who did not also use menopausal hormone therapy, according to findings published in Thyroid.