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November 29, 2021
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FDA grants RMAT designation to CRISPR-edited CAR-T for advanced B-cell malignancies

FDA grants RMAT designation to CRISPR-edited CAR-T for advanced B-cell malignancies

The FDA granted regenerative medicine advanced therapy designation to CTX110, a chimeric antigen receptor T-cell therapy in development for treatment of relapsed or refractory B-cell malignancies.

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November 19, 2021
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VIDEO: Better understanding of malignant lesion development, ‘promising’ future of CRISPR

VIDEO: Better understanding of malignant lesion development, ‘promising’ future of CRISPR

In this video, Lillian L. Siu, MD, FRCPC, discusses two keynote presentations at AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics.

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October 27, 2021
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VIDEO: CRISPR potential very diverse for treatment of cancer

VIDEO: CRISPR potential very diverse for treatment of cancer

In this video, Stan Lipkowitz, MD, PhD, chief of the women's malignancies branch in the National Cancer Institute's Center for Cancer Research, discusses the keynote talk on CRISPR presented at AACR-NCI-EORTC.

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October 21, 2021
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Top in hem/onc: CRISPR produces ‘life-altering’ changes, male allyship in medicine

Top in hem/onc: CRISPR produces ‘life-altering’ changes, male allyship in medicine

The CRISPR/Cas9 gene-editing system is producing results that may transform the treatment of certain diseases, according to Nobel Prize winner Jennifer A. Doudna, PhD.

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October 14, 2021
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CRISPR-edited CAR-T appears safe, effective for advanced large B-cell lymphoma

CRISPR-edited CAR-T appears safe, effective for advanced large B-cell lymphoma

More than half of patients who received a single dose of CTX110 for relapsed or refractory large B-cell lymphoma responded to therapy, according to topline data released by the agent’s manufacturer.

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October 14, 2021
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CRISPR editing can produce ‘life-altering’ changes in patient health, Nobel laureate says

CRISPR editing can produce ‘life-altering’ changes in patient health, Nobel laureate says

The CRISPR/Cas9 gene-editing system already is producing results that may fundamentally transform the treatment of certain diseases, according to one of the recipients of the 2020 Nobel Prize in Chemistry.

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September 17, 2021
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FDA clears IND application for CRISPR-edited T-cell receptor therapy to treat AML

FDA clears IND application for CRISPR-edited T-cell receptor therapy to treat AML

The FDA cleared an investigational new drug application for NTLA-5001, a T-cell receptor T-cell therapy designed to treat adults with relapsed or refractory acute myeloid leukemia.

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September 16, 2021
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FDA grants fast track designation to CRISPR-edited stem cell therapy for AML

FDA grants fast track designation to CRISPR-edited stem cell therapy for AML

The FDA granted fast track designation to VOR33, an engineered allogeneic stem cell therapy for the treatment of patients with acute myeloid leukemia who are at high risk for relapse.

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August 24, 2021
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CRISPR gene editing may put universal T-cell therapy within reach

CRISPR gene editing may put universal T-cell therapy within reach

Few scientific advances have generated the optimism and enthusiasm that surround CRISPR.

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June 16, 2021
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TP73 gene mutations indicate risk for ALS

An analysis of exome sequences in patients with ALS and healthy controls “strongly” indicated that variants in the TP73 gene are associated with risk for ALS, according to study results published in Neurology.

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