Bleeding
In AF, LAA closure may be best suited for patients at low stroke risk, high bleeding risk
In a decision analysis comparing left atrial appendage occlusion and oral anticoagulation in atrial fibrillation, left atrial appendage occlusion tended to be favored when patients were at low risk for stroke and high risk for bleeding.
Adding ticagrelor to aspirin reduces vein graft failure, increases bleeding after CABG
Compared with aspirin alone, aspirin plus ticagrelor was associated with reduced risk for vein graft failure and increased risk for clinically important bleeding in patients who underwent CABG, according to a meta-analysis.
Novel gene therapy reduces bleeding events, need for factor IX infusions in hemophilia B
A single infusion of verbrinacogene setparvovec resulted in normal factor IX levels among all 10 men who received the investigational gene therapy for moderate to severe hemophilia B, study results showed.
‘Less ominous’ short-term, long-term outcomes with isolated vs. proximal DVT
Adults with isolated distal deep vein thrombosis experience fewer short- and long-term adverse outcomes compared with those with proximal DVT, including major bleeding and venous thromboembolism deterioration, data show.
Sperling: Messaging around aspirin could be better
PHILADELPHIA — The question of who should take aspirin is a complicated one and public messaging on it is sometimes confusing, a speaker said at the Heart in Diabetes CME conference.
Early beta-blocker use post-PCI tied to reduced in-hospital bleeding risk
Initiation of oral beta-blockers within 24 hours following PCI for ACS was associated with reduced risk for in-hospital bleeding and mortality compared with nonuse, researchers reported.
Long-term clopidogrel confers less MACCE, bleeding events vs. aspirin after PCI
ATLANTA — Clopidogrel monotherapy after 12 months of event free post-PCI dual antiplatelet therapy was associated with fewer MACCE and bleeding events vs. aspirin monotherapy in high bleeding risk patients, a speaker reported.
POISE-3
Tranexamic acid vs. placebo for life-threatening, major and critical organ bleeding in patients undergoing noncardiac surgery.
DAPT for 1 month beneficial in complex PCI with biodegradable stent, high bleeding risk
In patients with high bleeding risk who underwent complex PCI, dual antiplatelet therapy for approximately 1 month reduced bleeding compared with slightly longer DAPT duration, according to new data from the MASTER DAPT trial.
Some needs unmet in secondary CVD prevention despite aspirin use; new agent may have role
Aspirin is the foundational treatment for secondary prevention of cardiac events and the standard therapy I have used for my patients for decades, but it can expose some patients to bleeding risk.