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Top pulmonology news from August: Updates on vaping-related lung disease, asthma treatments, critical care
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Healio Pulmonology has you covered. The Editors have compiled a list of the most-popular articles posted on Healio Pulmonology in August.
See below for links to coverage of the growing number of cases of lung disease associated with vaping, a study on the use of open lung ventilation in acute respiratory distress syndrome, the potential for azithromycin to increase antibiotic resistance in asthma and more.
Open lung ventilation fails to reduce ventilator-free days in ARDS
New data from the PHARLAP trial indicated that a maximal lung recruitment strategy, compared with conventional mechanical ventilation, had no effect on the number of ventilator-free days or mortality in patients with acute respiratory distress syndrome. Read more
AMAZES: Azithromycin may increase antibiotic resistance in severe asthma
In a substudy of the AMAZES trial, azithromycin, when used as a treatment for exacerbations in patients with severe asthma, reduced Haemophilus influenzae load but also increased resistance to antibiotics, researchers reported in the American Journal of Respiratory and Critical Care Medicine. Read more
Targeted lung denervation safely reduces respiratory events in COPD
Among patients with COPD, targeted lung denervation in addition to optimal pharmacotherapy, as compared with pharmacotherapy alone, was associated with fewer respiratory events including exacerbations, according to data from the AIRFLOW-2 study. Read more
FDA, CDC outline steps to combat pulmonary disease possibly linked to vaping
In a statement released by the FDA, as of Aug. 27, one death and 215 possible cases of severe lung disease associated with use of electronic cigarettes, or vaping, have been reported in 25 states and additional reports are under investigation. Read more
For additional coverage of the cases of severe lung disease possibly associated with e-cigarette use, read more .
Budesonide-formoterol reliever therapy outperforms maintenance plus as-needed therapy for preventing asthma exacerbations
Data from the PRACTICAL study showed that budesonide-formoterol reliever therapy in a single inhaler for patients with mild to moderate asthma was associated with a 31% reduction in the risk for severe exacerbations, as compared with maintenance budesonide plus terbutaline reliever therapy. Read more
Mortality risk higher with severe hyperoxemia in pediatric ICU
Critically ill children who experience severe hyperoxemia in the pediatric ICU may have a higher risk for in-hospital mortality, according to data published in JAMA Network Open. Read more
OSA traits help identify patients responsive to oral appliance therapy
Certain traits can be used to identify patients with a type of obstructive sleep apnea that is highly responsive to oral appliance therapy, a recent secondary analysis of polysomnographic data suggests. Read more
Metformin may lower risk for exacerbations in patients with asthma, diabetes
Metformin treatment may lower the risk for asthma exacerbations in patients with diabetes, a recent retrospective cohort study suggested. Read more
Osteoporosis prevalent in patients with COPD
More than one-third of patients with COPD worldwide may have osteoporosis, according to a systematic review and meta-analysis published in CHEST. Read more
Chronic cough in asthma linked to more severe disease
Among patients with asthma, those with chronic cough vs. without chronic cough had worse respiratory symptoms, more health care use, lower lung function and higher levels of inflammatory biomarkers, according to a Danish study published in the Journal of Allergy and Clinical Immunology: In Practice. Read more