Experts explore potential of psychedelics in mental health

SAN DIEGO — In a presentation here, researchers reviewed evidence of the utility of psychedelic substances for treatment of mental health disorders.

“We have evidence that psychedelic substances have been used by humanity for at least 7,000 years. One of the earliest depictions we have is a cave painting, which we call ‘The Shaman.’ Also in history, there’s a strong correlation, particularly in Christianity, with psychedelic substances, which has been documented in several different books,” Matthew Brown, DO, MBA, of Rogers Behavioral Health, said.

There has been a new wave of interest in psychedelic substances during the last decade, with several studies suggesting clinical potential, according to Brown.

A study in JAMA Psychiatry indicated individuals with cancer who ingested psilocybin exhibited significant decreases in anxiety.

Findings in Lancet Psychiatry showed psilocybin improved depressive symptoms in treatment-resistant depression.

However, the neuroscience behind psychedelics is not yet well understood.

A neuroimaging study that utilized functional MRI showed a decrease in blood oxygen flow in the restrosplenal and parahippocampal cortex, which may explain ego disintegration and other psychedelic effects.

Further, several neurotransmitters, including serotonin and glutamate, have been associated with psychedelic effects.

Despite these findings, evidence is preliminary and more research is needed on the efficacy of psychedelic substances for treatment of mental health disorders, according to Brown and colleagues. – by Amanda Oldt

Reference:

Brown M, et al. Psychedelics and psychiatry: Past, present and future. Presented at: American Psychiatric Association Annual Meeting; May 20-24, 2017; San Diego.

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