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Pregnant women preferred alternatives to antidepressants

Pregnant women with depression are more likely to prefer non-pharmacologic treatment over antidepressant medications, according to data from a mixed-methods study. Additionally, Cynthia L. Battle, PhD, of the Warren Alpert Medical School of Brown University, and Women and Infants' Hospital of Rhode Island, and colleagues report that many women expressed a large degree of uncertainty about how to treat their depression.

In-depth interviews were conducted with 61 pregnant women from a longitudinal study on the effects of prenatal antidepressant use and prenatal maternal depression on fetal and neonatal outcomes, according to a press release. Interviews aimed to determine psychiatric diagnoses, symptoms and functional impairment. In addition, researchers interviewed women about their preference for treatment of depression, concerns and decision-making patterns. About half of the women were clinically depressed.

Cynthia L. Battle

During pregnancy, about 70% of the women with depression received some form of treatment, although they often reported conflictual feelings regarding depression treatment decisions during this time. Specifically, one-third of women reported a high degree of uncertainty and confusion; these women had higher levels of depression and were less likely to engage in treatment, according to the press release.

Women were more likely to prefer non-pharmacologic treatments, such as psychotherapy and alternative therapies, and many said they would only consider using antidepressants during pregnancy as a "last resort." According to the press release, concerns included fear of possible adverse effects in the developing baby, including symptoms of withdrawal, premature delivery and childhood learning problems; feelings of shame, guilt and confusion about using antidepressants during pregnancy; and the potential for the infant to become dependent on antidepressants.

Disclosure: The researchers report no relevant financial disclosures.