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Population susceptibility to rotavirus may have shifted following vaccine introduction
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SAN DIEGO — Results from a population-based study presented here suggest that population susceptibility to rotavirus may have shifted following the introduction of rotavirus vaccine.
Natasha Halasa, MD, MPH, of Vanderbilt University, and colleagues assessed population-based surveillance data for children aged 14 days to 18 years who presented with acute gastroenteritis to EDs and outpatient clinics in Davidson County between December 2012 and September 2014. The study cohort included 2,221 patients who presented with acute gastroenteritis and 1,094 healthy controls.
Researchers assessed stool specimens to determine the proportion of acute gastroenteritis visits due to rotavirus, norovirus, sapovirus and astrovirus during the study period.
Natasha Halasa
Overall, viruses were detected in 45.3% of patients with acute gastroenteritis and 16.3% of healthy controls.
Among children with acute gastroenteritis, norovirus was detected in 20.3%, rotavirus was detected in 13%, sapovirus was detected in 11.6% and astrovirus was detected in 5.8%.
Among controls, norovirus was detected in 7.7% of samples, sapovirus was detected in 5.1%, rotavirus was detected in 3% and astrovirus was detected in 2.5%.
Analysis indicated that 91% of norovirus samples were genogroup II and of these, geneotype 4 was the most common.
“Viral detection was more common in gastroenteritis cases compared with controls,” Halasa said during a presentation. “The most common norovirus genogroup was GII, the most common rotavirus genotype was G12.P8, and unlike other gastroenteritis viruses, rotavirus was detected more commonly in the older children, suggesting an older, unvaccinated susceptible population.” – by Amanda Oldt
Reference:
Halasa N, et al. Abstract #1180.6. Presented at: Pediatric Academic Societies 2015; April 25-28, 2015; San Diego.
Disclosure: Halasa reports no relevant financial disclosures. Please see the full study for a list of all other authors’ relevant financial disclosures.