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Common traits identified among serotype 1 invasive pneumococcal disease
Serotype 1 invasive pneumococcal disease may be more typically found in older children and children with underlying disease and more frequently associated with bacteremia than other most common serotypes, according to study data published online.
David Greenberg, MD, of the pediatric infectious disease unit at Soroka University Medical Center in Beer-Sheva, Israel, and colleagues looked at invasive pneumococcal disease (IPD) data for all children treated at the hospital between 2000 and 2009.
David Greenberg
The researchers noted 250 episodes of IPD associated with Israel’s most common serotypes: 5, 14, 6A, 6B, 19A, 19F and 23F. Ninety-four episodes were associated with serotype 1.
Serotype 1 was more commonly seen and persisted in older children, whereas the most common serotypes as a group and individual serotypes decline in frequency after 23 months, according to the researchers.
“Serotype 1 is recognized worldwide as one of the most virulent serotypes among more than 92 S. pneumoniae serotypes. It infects both children and adults,” Greenberg told Infectious Diseases in Children.
The researchers also said serotype 1 was more often associated with bacteremic pneumonia and primary peritonitis compared with more commonly reported serotypes. Serotype 1 was also more common among Bedouin children.
However, the researchers said mortality and hospitalization rates were similar between the two groups.
“Pneumonia is the most common diagnosis in patients across all ages. The pneumococcal conjugated vaccines (10-valent and 13-valent) included this important serotype in their formularies. It is anticipated that following the introduction of these vaccine in the national immunization programs in many countries, serotype 1-related disease will be reduce significantly worldwide,” Greenberg said.
David Greenberg, MD, can be reached at dudi@bgu.ac.il.
Disclosure: Greenberg reports no relevant financial disclosures.
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