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Fractional dose of IPV induced immune response in Cuba infants
A single fractional dose of inactivated poliovirus vaccine induced priming immune responses in infants aged younger than 8 months, according to study results published online.
Roland W. Sutter, MD, MPH, of WHO, and colleagues from the Pedro Kouri Institute in Havana reported immunogenicity data on 310 Cuban infants who were randomly assigned to receive either fractional (one-fifth of a full dose) or a full dose of IPV at ages 4 and 8 months.
In the group of infants who received the intradermal fractional dose of IPV, a priming immune response occurred in 90.8%, 94% and 89.6% of infants vs. 97.6%, 98.3% and 98.1%, respectively, of those infants who received an intramuscular full dose of poliovirus vaccine, given intramuscularly, that included types 1, 2 and 3.
The researchers said infants who received the fractional dose reported a greater number of adverse events; however, all adverse events were characterized as minor and resulted in no serious consequences.
“This trial also expands the number of policy options that could make IPV affordable for use in developing countries,” Sutter and colleagues said.
Disclosure: Sutter reports no relevant financial disclosures.
Roland W. Sutter, MD, MPH, can be reached at sutterr@who.int.
