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Researchers identify genes that may cause strabismus

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Researchers at Okayama University reported that they have identified two candidate genes involved in the development of comitant strabismus.

These findings provide insight into how people maintain eye alignment for depth perception, according to a press release from Okayama University.

Toshihiko Matsuo, MD, and colleagues used single nucleotide polymorphism (SNP) to analyze the DNA of 204 individuals in 58 Japanese families; 108 of the subjects had comitant strabismus with both esotropia and exotropia.

The transmission disequilibrium test (TDT) and the TDT allowing for errors — essentially, statistical tests on paired data — and a linkage analysis under dominant and recessive inheritance pointed to two genes as potential loci of the SNP for comitant strabismus, abbreviated MGST2 and WNT2, according to the release.

It was already known that MGST2 and WNT2 are expressed in the brain, and these researchers showed that the two genes are likely to play a role in the development of comitant strabismus, the press release said.