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Literature review confirms efficacy of cyclosporine against dry eye symptoms
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A review of the literature evaluating the effects of cyclosporine (CsA) ophthalmic emulsion 0.05% as a treatment for dry eye found that the drug provides effective relief of symptoms.
The search was conducted on PubMed and was limited to papers published or translated into English between 1986 and March 2017, with no restriction on the study design.
A review of the important conclusions of individual studies or groups of studies on specific topics was conducted and briefly summarized. Topics included cyclosporine (CsA) and topical steroids, CsA in the Asian population, CsA dosages, CsA vs. topical vitamin A and several others. No overall pooling and statistical analysis of data was performed.
The authors, however, were able to conclude that “the evidence for objective parameter response to CsA 0.05% [twice daily] in dry eye disease is strong, but subjective results are less consistent. The lack of correlation in signs and symptoms is an inherent challenge of the disease.”
Later in the conclusion they stated that, “Despite the variability and limitations of study design and study end points, in general, CsA ophthalmic emulsion 0.05% [twice daily] appears to have utility in symptomatic relief in people with chronic dry eye.” – by Michela Cimberle
Disclosure: Rhee reported no financial disclosures. Please see the study for the other author’s financial disclosures.
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