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Adding hyaluronic acid to standard rewetting drop improves clinical performance
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Dryness and burning/stinging throughout the day showed more improvement in contact lens wearers using a rewetting drop with both carboxymethylcellulose and hyaluronic acid over a 3-month period, according to researchers in Optometry and Vision Science.
The randomized, parallel-group, 90-day study was conducted at 15 clinical sites. Subjects were randomized 2:1 to carboxymethylcellulose and hyaluronic acid (CMC-HA) in 244 subjects or CMC alone in 121 subjects. Dosage was at least four times per day.
CMC-HA also performed numerically better for dryness at the end of the day. Lid wiper epitheliopathy (LWE) staining was improved in the CMC-HA group at day 90, but increased slightly in the CMC alone group, with a significant between-group difference, according to researchers.
Conjunctival staining was also reduced in the CMC-HA group compared to the CMC alone group at day 90.
The researchers support the use of LWE as a tool for diagnosing ocular dryness and monitoring effectiveness of lubricating agents. – by Abigail Sutton
Disclosure: Nichols reported no relevant financial disclosures. This study was sponsored by Allergan plc, Dublin, Ireland. Please see the full study for all remaining authors’ relevant financial disclosures.
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