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Drug release affected by contact lens material, system used
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Researchers observed a higher fluconazole release in the vial compared with an eye model, as well as differences in drug release among contact lens materials.
Phan and colleagues reported in Optometry & Vision Science that they incubated four commercial daily disposable conventional hydrogels (nelfilconA, etafilcon A, ocufilcon B) and three silicone hydrogels (somofilcon A, narafilcon A, delefilcon A) with fluconazole for 24 hours.
They measured drug release in a vial containing 4.8 mL of phosphate-buffered saline and in a three-dimensionally printed polydimethylsiloxane eye model with a 4.8 mL tear flow across 24 hours.
Conventional hydrogel contact lenses had a higher uptake and release of fluconazole than silicone hydrogel contact lenses, according to researchers.
They also reported that they found a higher drug release in the vial condition within the first 2 hours, followed by a plateau phase, and a sustained drug release in the eye model that did not reach a plateau across 24 hours.
“These results indicate that the parameters of the release system also need to be taken into consideration when making conclusions about the properties of a contact lens material,” the researchers wrote. –by Abigail Sutton
Disclosure: The researchers reported no relevant financial disclosures.
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