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Study: Melimine-coated contact lenses safely provide antimicrobial benefits
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In a recent Optometry and Vision Science study designed to evaluate melimine-coated contact lenses, researchers found that the lenses retained high antibacterial activity after wear.
Dutta and colleagues also discovered that the melimine-coated lenses were associated with higher corneal staining.
Researchers used lenses in which melimine was covalently bonded to the surface of the contact lenses using 1-ethyl-3-[3-dimethylaminopropyl] carbodiimide hydrochloride coupling. After determining that the lenses were safe via a trial with rabbits, researchers conducted a prospective, randomized, double-masked, 1-day human clinical trial.
In the human trial, researchers analyzed subjective responses and ocular physiology while the 17 participants wore a melimine-coated lens in one eye and an uncoated lens in the other. They also monitored reactions in several follow-up visits.
Results showed that the researchers found no differences in wettability, surface deposition, lens-fitting centration, movement, tightness and corneal coverage between melimine-coated and uncoated lenses. Additionally, there were no significant differences in lens comfort, dryness, awareness, bulbar, limbal or palpebral redness or conjunctival staining.
As detailed in the study, the results also demonstrated that the melimine-coated lenses were associated with significantly higher levels of corneal staining.
"This study has shown that melimine-coated contact lenses can be safely worn by humans without any major side effects," the authors concluded. "It is supported by animal study, and the antimicrobial benefit could be achieved without any adverse effect on mammalian eye health. Although melimine lenses were less preferred, subjective comfort scores were broadly comparable to those of uncoated control lenses. Melimine lens wear was associated with a higher corneal staining and retained antibacterial activity against P. aeruginosa and S. aureus after wear. Given the period of human contact lens wear, melimine lenses were biocompatible and retained antibacterial activity."
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Optom Vis Sci. 2014; doi: 10.1097/OPX.0000000000000232.
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