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Study: Combination therapy effective in dry eye after LASIK
A study recently published in the American Journal of Ophthalmology found that hyaluronate and diquafosol administered together is beneficial to visual acuity and dry eye symptom management in patients post-LASIK.
The prospective randomized trial included 206 eyes of 105 patients who underwent LASIK, according to the study abstract.
Patients were randomly assigned one of four treatment groups: artificial tears, sodium hyaluronate, diquafosol tetrasodium and a combination of hyaluronate and diquafosol. Questionnaire responses reflecting subjective dry eye symptoms, uncorrected and corrected visual acuity, functional visual acuity, manifest refraction, tear break-up time, fluorescein corneal staining, Schirmer’s test, and corneal sensitivity were examined before and 1 week and 1 month after LASIK, the abstract stated.
Distance visual acuity and near uncorrected visual acuity was significantly better in the combination group, the authors reported. Distance functional visual acuity improved significantly only in the combination group 1 month after LASIK. Dry eye symptoms in the combination group improved significantly compared with those in the other groups 1 week after surgery.
Toda and fellow researchers concluded that hyaluronate and diquafosol combination therapy is beneficial for early stabilization of visual performance and improvement of subjective dry eye symptoms after LASIK.
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Toda I, et al. Am J Ophthalmol;doi: 10.1016/j.ajo.2013.11.017.