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Prophylactic drops have no effect on inflammatory events in continuous wear
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Researchers found that twice-daily instillation of antibiotic drops has no significant effect on the incidence of inflammation in patients wearing contact lenses overnight; however, corneal infiltrative events were associated with higher levels of lens contamination.
Ozkan and colleagues reported in Optometry and Vision Science that they evaluated 241 patients who wore lotrafilcon A silicone hydrogel lenses continuously for 30 days. The subjects were randomized to receive either moxifloxacin 0.5% or a rewetting drop once at bedtime and once upon waking. The patients were followed up at 1 night and 1 month, and lid margin swabs were taken at baseline and at 1 month. The lenses were collected after 1 month of wear, according to the abstract.
The incidence of corneal infiltrative events was not significantly different between the antibiotic group (2.6%) and the rewetting drop group (3.9%), the researchers reported. However, the microorganism levels from the antibiotic group’s swabs were significantly lower than those from the control group. Gram-positive bacteria were less frequently detected on the lids or contact lenses of the antibiotic group; however, gram-negative bacteria showed no difference.
Corneal infiltrative events were associated with higher levels of lens contamination in general and with contamination by GNB specifically, Ozkan and colleagues concluded.
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