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Study to determine rate of dry eye progression underway
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Preliminary results from the Progression of Ocular Findings Study revealed baseline differences between dry eye and control groups, according to a press release from Alcon.
According to the release, the study showed that dry eye subjects had higher mean scores for Ocular Surface Disease Index, corneal staining and conjunctival staining, as compared to the control group. They also had lower mean scores for Schirmer’s test, tear break-up time and temporal goblet cell density.
The study will be conducted over the course of 5 years at multiple centers and aims to determine the natural rate of progression of dry eye disease in patients with moderate dry eye. It will include 268 patients; 217 demonstrated level 2 dry eye at baseline and the remaining 51 were designated as controls, the release said.
More than half (58.5%) of dry eye subjects and 13.7% of control subjects reported moderate, severe or very severe blurred vision at baseline, it said.
Enrolled subjects will be followed 6 months at a time to determine the percentage for whom dry eye progresses beyond baseline measures, the release said.
Peter J. McDonnell, MD, of Johns Hopkins Wilmer Eye Institute presented the findings at the Association for Research in Vision and Ophthalmology meeting.