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Visual field, OCT results show poor correlation in advanced RNFL loss

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SAN FRANCISCO - A retrospective study of patients with early to advanced glaucoma showed a wide variation in mean deviation in patients with advanced retinal nerve fiber layer loss when comparing visual field sensitivity with retinal nerve fiber layer thickness.

Jessica Neuville, OD, presented a study here at Academy 2010 involving 44 men and four women between 37 and 87 years of age. The patients were evaluated using the Humphrey 30-2 Visual Field Analyzer (Carl Zeiss Meditec, Dublin, Calif.) and the Cirrus HD-OCT (Carl Zeiss Meditec).

The study found moderate correlation between mean deviation and average RNFL, but advanced RNFL had a wide variation in mean deviation.

"These results suggest that OCT is moderately correlated to visual function in early loss, but is a poor predictor of visual function at advanced levels of RNFL loss," Dr. Neuville said. "Also in this study, as well as previous studies using OCT, the relationship between RNFL and mean deviation is curvilinear."

There was no correlation between pattern standard deviation and no difference between superior and inferior RNFL thickness. There was also no correlation noted between the difference in mean deviation and difference in average RNFL thickness.