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July 06, 2023
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Reverse four-throw pupilloplasty allows knot formation on posterior surface of iris

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In this column, we will describe a simple and novel method of performing a pupilloplasty procedure that allows adequate pupil reconstruction.

The technique of reverse four-throw (RFT) pupilloplasty works on the principle of formulating four throws, which allows a self-sealing and self-locking knot to form as in the single-pass four-throw technique of pupilloplasty. RFT pupilloplasty allows knot formation on the posterior surface of the iris, unlike other techniques that have the knot lying on the anterior iris surface with the suture ends protruding in the anterior chamber.

Reverse four-throw pupilloplasty, part 1
1. Reverse four-throw pupilloplasty, part 1. Glued IOL completed. Note the optic capture (a). Prolene needle with suture is passed through the clear cornea and then through the posterior surface of the iris. Note the nondominant hand holding the iris with end-opening glued IOL forceps to help pass the Prolene needle through the iris (b). A 30-gauge needle passes through a paracentesis and then through the posterior surface of the iris. Once again, note the opposite hand holding the iris with end-opening glued IOL forceps to help the needle pass through the iris (c). Prolene needle is railroaded into the barrel of the 30-gauge needle (d).

Source: Rhea Narang, Priya Narang, MS, and Amar Agarwal, MS, FRCS, FRCOphth

Technique

Two paracentesis incisions are made: one at the distal end and another midway between the proximal and distal iris defect. The placement of the incision depends on the surgeon’s preference.

End-opening forceps introduced from the proximal paracentesis incision hold the proximal iris defect. A 9-0 polypropylene suture on a long arm needle is introduced, engaging the proximal iris from the posterior surface to emerge on the anterior surface of the iris. Meanwhile, a 27- or 30-gauge needle is introduced from the distal paracentesis incision, and it pierces the distal defect from the posterior side to emerge on the anterior surface of the iris (Figures 1a to 1d). The suture needle is threaded into the barrel of the needle and eventually pulled out of the anterior chamber.

Amar Agarwal
Amar Agarwal
Priya Narang
Priya Narang

A Sinskey hook is passed through the distal paracentesis, and the suture loop is withdrawn. The suture end is passed through the loop four times (in the same direction), and both suture ends are pulled (Figures 2a to 2d). The suture knot eventually slides inside the anterior chamber approximating the iris defect, with a difference that the knot lies on the posterior surface of the iris. The suture ends are cut with end-opening scissors.

Reverse four-throw pupilloplasty, part 2
2. Reverse four-throw pupilloplasty, part 2. The single pass loop is brought out through the paracentesis (a). Four throws are passed into the loop, just like in single-pass four-throw pupilloplasty (b). The two ends are pulled so that a Siepser sliding knot is created (c). The ends of the suture are cut, and the knot now lies behind the iris and cannot be seen (d).

Discussion

This technique could be especially beneficial for cases scheduled for endothelial keratoplasty. Absence of suture knots and tails in the anterior chamber can be helpful as the endothelial graft typically lands in the center of the pupil that harbors the suture knots and tails, which can potentially harm the endothelial cells of the donor graft. During the process of graft unrolling, the anterior chamber is kept shallow. At this stage, further manipulation can debride the endothelial cells as the suture knots and tails can rub against the graft. The suture knot in RFT is not detected on anterior segment OCT, and the iris plane is depicted as a flat surface.