Ultra-widefield imaging yields predictive data for diabetic retinopathy worsening
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KOLOA, Hawaii — Ultra-widefield fluorescein angiography may enable more sensitive and specific methods to predict diabetic retinopathy worsening compared with standard FA, Paolo S. Silva, MD, said at Retina 2023.
More than 80% of nonperfusion in diabetic eyes is located outside the posterior pole and ultra-widefield FA allows assessment of nonperfusion in retinal mid- and far peripheral zones, which are not covered by standard ETDRS FA imaging, Silva said.
“With the use of ultra-widefield imaging devices, we are now able to perform angiography that captures a high-resolution, 200-degree field that encompasses a single angiographic phase,” Silva said. “This allows for a full evaluation of the retinal periphery, assessment of the impact of DR severity and the potential for progression.”
Study data from DRCR Retina Network Protocol AA supports the evaluation of retinal nonperfusion identified on ultra-widefield FA as risk factors for both anatomic and visual outcomes in diabetic eyes, he said.
“In eyes with [nonproliferative diabetic retinopathy], worse DR severity was consistently associated with increasing nonperfusion on FA,” Silva said. “Nonperfusion was located primarily in the mid-peripheral retina across all DR severity levels.”
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Silva PS. Ultra-widefield fluorescein angiography: What lies unseen? Presented at: Retina 2023; Jan. 15-20, 2023; Koloa, Hawaii.
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