Glomerular Disease Clinical Case Review

In this video, Craig Gordon, MD, nephrologist at Tufts Medical Center and associate professor of medicine at Tufts University School of Medicine, discusses the chosen therapy in this case of lupus nephritis:

Editor’s note: The following is an automatically generated transcript of the above video.

"We have, as we recall, a patient who had a combination of class IV and class V lupus with quite remarkable elevation in the level of proteinuria. So the decision was made early on after that first three-day course of pulse corticosteroids to start relatively high-dose oral prednisone with a plan for a fairly rapid taper. Given her young age, as well as some other factors, the decision was made to choose mycophenolate, which began at low dose, and the dose was increased once weekly, up to a target which was achieved of 1500 milligrams twice daily. And when we considered would this be adequate, we had concerns about the quite significant proteinuria and nephrotic syndrome, and made the decision to treat the patient with voclosporin (Lupkynis, Aurinia), which was 23.7 milligrams twice daily."