Renal angina indices may help predict AKI risk among patients in ICU
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Key takeaways:
- At 24 hours, measured area under the curve for the Matsuura index was 0.74, researchers found.
- Urinary biomarkers did not enhance the predictive accuracy of renal angina indices.
SAN DIEGO — Renal angina indices may help predict AKI risk in patients who are critically ill and hospitalized in the ICU, according to data presented at ASN Kidney Week.
Erick Yasar, Zuñiga Gonzalez, MED, of the Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran in Mexico City, and colleagues ran a prospective cohort study to assess 134 patients in two level 3 hospital ICU centers in Mexico City. Researchers aimed to outline the predictive ability of renal angina indices, as well as urinary biomarker incorporation, for stage 2 or 3 AKI at 24 hours and 72 hours after admission.
Researchers collected demographic information, laboratory data and urine samples at the time of ICU admission and calculated renal angina index scores using Matsuura, Ortiz-Soriano and Del Toro-Cisneros methods. AKI was defined based on Kidney Disease: Improving Global Outcomes standards.
Of the patients assessed, 19 developed stage 2 or stage 3 AKI during 72-hour follow-up.
The Matsuura index had the highest predictive performance in receiver-operating characteristic analysis, according to the researchers. At 24 hours, it had an area under the curve of 0.74 (95% CI, 0.57-0.90). At 72 hours, area under the curve was 0.70 (95% CI, 0.56-0.84).
Adding the urinary biomarkers neutrophil gelatinase-associated lipocalin and heat shock protein-72 to the renal angina indices did not improve the receiver-operating characteristics curve or the discrimination capabilities of the indices, the researchers found.
Urinary biomarkers also did not enhance the predictive accuracy of renal angina indices for severe AKI, suggesting these indices could be integrated into routine clinical assessments, according to Gonzalez.
“Renal angina indices [alone may] not be as good as we think, but the use of both renal angina indices and urinary biomarkers changes this,” Gonzalez told Healio.
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Gonzalez EY, et al. FR-PO048. Presented at: ASN Kidney Week; Oct. 24-27, 2024; San Diego.
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