Oxiris membranes offer no advantage vs. standard membranes for hemodynamic stability
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Key takeaways:
- Researchers found no differences in mean arterial pressure between experimental and control groups.
- The rate of vasopressor use was also similar between groups.
SAN DIEGO — Oxiris membranes may offer no clinical advantage vs. standard membranes to maintain hemodynamic stability in patients with septic shock who need continuous kidney replacement therapy, data presented at ASN Kidney Week show.
“This is a study where we compare Oxiris membrane performance in patients with septic shock [to a standard membrane],” Omar Fueyo Rodriguez, of the Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran in Mexico City, told Healio. “In previous studies, it [has been] shown that Oxiris can [perform] better in [dynamic], stability and other outcomes.”
Researchers performed a controlled trial in which 30 critically ill patients who required continuous kidney replacement therapy were randomly selected for continuous veno-venous hemodiafiltration with Oxiris (Oxiris, Baxter) or a standard membrane.
The multicenter trial compared the effectiveness of the two therapies in maintaining mean arterial pressure after 72 hours. All participants were treated with a 30 mL/kg/h dose of regional citrate anticoagulation, with filter changes every 24 hours. Researchers accounted for clinical variables and vasopressor dependency.
Among the cohort, 50% of patients were in the experimental group, 46% were controls and one died.
The main infection was pneumonia, with 28% of cases linked to COVID-19, Rodriguez said.
Researchers found no differences in mean arterial pressure between groups at 0, 24, 48 and 72 hours. Initial readings were 66 mmHg for the experimental group and 68 mmHg for controls. After 72 hours, the values improved to 73 mmHg and 79 mmHg, respectively.
The rate of vasopressor use was similar between groups.
Rodriguez and colleagues noted higher fluid removal among controls. At 24 hours, the median fluid removal rate was 1.2 L for controls vs. 0.5 L for the experimental group. At 72 hours, controls averaged 1.5 L vs. 0.7 L in the experimental group. No differences were found in daily fluid balance.
Results of the study indicate that overall, “mean arterial pressure was stable,” according to Rodriguez. Researchers plan to extend the analysis beyond 72 hours and recruit more patients.
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Rodriguez OF, et al. TH-PO231. Presented at: ASN Kidney Week; Oct. 24-27, 2024; San Diego.
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