Study: More stringent algorithms may better define CKD stage G4
Click Here to Manage Email Alerts
Key takeaways:
- The 3-year risk of rapid progression among adults in the study cohort was 14.6%.
- The 3-year risks of kidney failure, hospitalization and death were 0.3%, 53.3% and 18.1%.
Chronic kidney disease stage G3 may be linked with considerable morbidity in a community-based setting, which shows a need for optimized early interventions, according to published data.
“We chose to investigate [CKD] because some of the patients experience rapid deterioration of their condition without us knowing exactly who,” study author Christian Fynbo Christiansen, MD, PhD, professor at the department of clinical medicine at Aarhus University, Denmark, said in a press release. “Our goal was to understand which patients are most at risk and whether we can intervene early to delay or even prevent this progression.”
Researchers studied 133,443 adults with incident CKD stage G3 in a population-based study in Denmark to examine the 3-year risk for rapid CKD progression, kidney failure, hospitalization and death. The nationwide trial, which ran from 2017 to 2020, defined rapid kidney progression by an eGFR decline of at least 5 mL/min/1.73 m2 per year, kidney failure, all-cause hospitalization and death.
Researchers created a heat map to highlight rapid progression risk based on albuminuria, sex, diabetes, and hypertension and cardiovascular disease as predefined markers.
Findings showed the 3-year risk of rapid progression among the cohort was 14.6%. The 3-year risks of kidney failure, hospitalization and death were 0.3%, 53.3% and 18.1%, respectively, according to the results. Christiansen and colleagues found in the heat map that the 3-year risk of rapid progression ranged from 7% in women without albuminuria, hypertension/cardiovascular disease or diabetes to as high as 46% to 47% in men and women with severe albuminuria, diabetes and hypertension/cardiovascular disease.
“This is an important finding since albumin can be used as an indicator of kidney disease progression, thereby making it possible to identify patients at high risk of rapid deterioration of the disease, and it can improve the prevention of complications and hopefully increase patients' quality of life," Christiansen said in the release.
Reference s :
- Study: Simple measurement can predict risk of worsening of widespread kidney disease (press release). https://health.au.dk/en/display/artikel/studie-simpel-maaling-kan-forudsige-risiko-for-forvaerring-af-udbredt-nyresygdom. Published Feb. 22, 2024. Accessed Mar. 4, 2023.
- Vestergaard AHS, et al. Nephrol Dial Transplant. 2024;doi.org/10.1093/ndt/gfad271.
Collapse
Click Here to Manage Email Alerts