Lower cellular respiration found in platelets of patients with CKD
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PHILADELPHIA — Cellular respiration was reduced in platelets and increased in peripheral blood mononuclear cells from patients with chronic kidney disease, according to data from a study presented at ASN Kidney Week.
Data were produced by an examination of 27 patients with stage 4 and 5 CKD in a study headed by Ayesan Rewane, MD, an internal medicine resident at the Baptist Health College of Medicine.
The combination of reduced cellular respiration in platelets and increased respiration in peripheral blood mononuclear cells has previously been noted in patients with severe chronic heart diseases but had yet to be fully examined in CKD.
Two-thirds of the study cohort were African American and 50% had diabetes. Median patient age was 61 years. Researchers performed the analysis using an Oroboros O2K-respirometer on intact and digitonin permeabilized cells, along with high-resolution respirometry to measure cellular respiration.
The findings indicated reduced cellular respiration in both the intact and permeabilized platelets, along with increased respiration in both intact and permeabilized peripheral blood mononuclear cells.
Rewane suggested that further study into the topic be performed to establish “whether these cellular phenotypes result in a proinflammatory CKD state that is associated with worse cardiorenal outcomes.”
Reference:
- Rewane A, et al. FR-PO1031. Presented at: ASN Kidney Week; Nov. 2-5, 2023; Philadelphia.
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