Racial disparities exist among patients with autosomal dominant polycystic kidney disease
Click Here to Manage Email Alerts
Researchers identified racial and ethnic disparities among patients with autosomal dominant polycystic kidney disease, according to data published in Kidney Medicine.
For example, Hispanic patients were the youngest to experience onset of kidney failure at 50 years old, and white patients were most likely to receive a kidney transplantation at 53.8%.
“An improved understanding of racial/ethnic differences in incidence and progression of autosomal dominant polycystic kidney disease (ADPKD) would provide insights into better managing this population,” Teresa N. Harrison, SM, from the department of research and evaluation at Kaiser Permanente Southern California, and colleagues wrote.
In a cross-sectional study, researchers examined data for 3,677 Kaiser Permanente Southern California members diagnosed with ADPKD between Jan. 1, 2002, and Dec. 31, 2018, to identify patients with ADPKD and kidney failure across races and ethnicities.
With ADPKD as the exposure, researchers observed kidney failure, dialysis or a transplantation as the primary outcomes of the study. Using ANOVA F test and Chi-squared tests, researchers measured differences in characteristics by race and ethnicity. Additionally, they conducted box plots and confidence intervals to compare the range and distribution of the average age at the start of kidney failure by race, ethnicity and sex.
Overall, 27.3% of the patients experienced kidney failure (138 patients were Black; 496 patients were white; 306 patients were Hispanic; and 87 patients were Asian). Kidney failure onset was earliest in Hispanic patients at 50 years old, then at 56 years old for Black patients and 57 years old for white patients.
White patients were more likely to have transplantation (53.8%) compared with Black and Hispanic patients (44.2% and 49.7%, respectively).
“In conclusion, among a large diverse ADPKD population from the southwestern United States, we observed racial/ethnic differences in rates of kidney failure, age of kidney failure onset and rates of kidney transplantation. Overall, Hispanic patients had the lowest kidney failure rates but had the youngest age at kidney failure onset. While overall kidney transplants and preemptive transplant rates were high in this ADPKD population, Black patients had the lowest rates of both,” Harrison and colleagues wrote. They added, “More insights into understanding ADPKD progression to kidney failure among different race and ethnicities may lead to improved and individualized management strategies for this [chronic kidney disease] CKD population.”
Collapse
Read more about
Click Here to Manage Email Alerts