VIDEO: Pafolacianine sodium improves intraoperative imaging in ovarian cancer
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In this video, Janos L. Tanyi, MD, PhD discussed findings from a study evaluating pafolacianine sodium combined with intraoperative near-infrared fluorescence imaging in patients with ovarian cancer.
Tanyi, an assistant professor in the department of gynecologic oncology at the University of Pennsylvania, presented data from the phase 3, randomized, multicenter, single-dose, open-label pivotal trial at the ASCO Annual Meeting.
The objective of the study was to confirm the safety and efficacy of a pafolacianine sodium infusion combined with near-infrared fluorescence (NIRF) imaging to detect additional lesions not detected by palpation and normal white light in patients with ovarian cancer who were scheduled to undergo cytoreductive surgery.
Results indicated that pafolacianine sodium combined with NIRF identified additional lesions not planned for resection in a significant number of patients. Adverse events were mild to moderate and mostly gastrointestinal in nature, with many resolving within 30 minutes after the infusion was stopped, according to the abstract.
Tanyi said that these findings suggest that this agent is a good adjunct to the surgeon to help reach more complete debulking.
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Tanyi JL, et al. Abstract 5503. Presented at: ASCO Annual Meeting (virtual meeting); June 4-8, 2021.
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