VIDEO: Novel assessment evaluates breast cancer risk in women of all ancestries
In this video, Holly Pederson, MD, assistant professor of medicine in the Cleveland Clinic Lerner College of Medicine of Case Western University, spoke with Healio about a novel polygenic risk score for breast cancer in all women, regardless of their ancestry.
Pederson presented data that showed that a 149-single-nucleotide polymorphism global polygenic risk score was validated and calibrated for all women.
She explained that while polygenic risk scores are a “powerful and individualized tool in the field of breast cancer,” a score had not previously been validated to assess risk among women of all ancestries.
“This new model provides a framework for a polygenic risk score that delivers a personalized genomic breast cancer risk assessment to any and all interested women,” she said. “It’s calibrated for women of European and non-European ancestry, and really may be the most exciting clinical development in risk-stratification — in my opinion — since the advent of multi-gene panel testing.”
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