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Take Homes in CAR T

Take Homes in CAR T-cell Therapy
ByFrederick L. Locke, MD

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December 09, 2020
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VIDEO: Myc expression may predict remission response in diffuse large B-cell lymphoma

ByFrederick L. Locke, MD
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Frederick Locke, MD, co-leader of the Immunology Program at Moffitt Cancer Center, discussed follow-up data from the JULIET trial presented at the ASH Annual Meeting and Exposition.

“Patients who had a high Myc expression by immunohistochemistry had worse outcomes. This is interesting because in the pivotal CAR T-cell therapy trials for diffuse large B-cell lymphoma, we haven't seen that double hit lymphoma or double expressor lymphoma has really been a predictor for worse outcomes. Here, they quite simply looked by immunohistochemistry for Myc expression,” Locke told Healio in a video interview.

Sources/Disclosures

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Source:

Jaeger, U et al. Abstract 1194. Presented at: ASH Annual Meeting and Exposition (virtual meeting); Dec. 5-8, 2020.

Disclosures: Locke reports holding a scientific advisory role for Allogene, Celgene, GammaDelta Therapeutics, Kite, Novartis and Wugen; and acting as consultant with grant options for Cellular Biomedicine Group Inc.

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b-cell lymphoma
car t-cell therapy
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