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VIDEO: Copper depletion affects tumor microenvironment in patients at high risk for breast cancer recurrence

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NEW ORLEANS — Linda T. Vahdat, MD, MBA, medical oncologist and director of the breast cancer research program at Weill Cornell Medicine and NewYork-Presbyterian, presented study results at the American Association for Cancer Research Annual Meeting that suggested a copper depletion strategy may affect the tumor microenvironment in women with breast cancer at high risk for relapse.

The analysis included 75 women who completed 2 years of treatment.

Results showed copper depletion reduced components of the tumor microenvironment that are copper dependent and are critical for tumor progression, including VEGFR-2–positive endothelial progenitor cells. The approach also decreased lysyl oxidase.

“Some of the preclinical data suggests that we are affecting the tumor microenvironment, and it’s a classic example of bench-to-bedside-and-back-again strategy,” Vahdat told HemOnc Today.