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Hispanics show lower survival vs. non-Hispanic whites for CRC
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HONOLULU — Hispanic patients diagnosed with colorectal cancer had a shorter overall survival compared with non-Hispanic whites, according to findings presented at ACG 2015.
"Hispanics are the largest and fastest growing ethnic group in the U.S.,” Daniel Pievsky, DO, RD, CNSC, resident, Rutgers New Jersey Medical School, Jersey City, said during his presentation. "Prior studies have shown that rates of GI cancers are higher in Hispanics than in non-Hispanic whites, but Hispanics have been an understudied population, so we decided to focus on that."
Pievsky and colleagues performed a retrospective study using data of all patients diagnosed with colorectal cancer at Hackensack University Medical Center, New Jersey, between 1993 and 2013. From self-administered questionnaires, the researchers found 2,146 CRC cases were diagnosed during the time period. Of these, 318 cases were among Hispanics and 1,828 were in non-Hispanic whites.
“We found that Hispanics were more likely to have poorly differentiated tumors at diagnosis and a lower overall median survival; 76 months vs. 180 months,” Pievsky said.
In addition, Pievsky said that compared to non-Hispanic white patients, Hispanics were more likely to have left-sided tumors (71% vs. 63%) and higher recurrence rates of CRC (13% vs. 4%; P < .0001).
Multivariate analysis showed married status (P < .0001); Hispanic ethnicity (P < .009); histologic grade (P < .003); and negative margins post-resection (P < .0001) to be independent predictors for survival. Univariate analysis showed tumor location to be a predictor of survival.
CRC was the primary cause of mortality in 23% of Hispanics compared with 12% of non-Hispanic whites (P < .0001), according to Pievsky’s presentation.
“Hispanics were diagnosed with colorectal cancer at younger ages than non-Hispanic whites and had decreased overall survival after diagnosis of colorectal cancer when compared with non-Hispanic whites,” Pievsky concluded. – by Melinda Stevens
Reference:
Pievsky D, et al. Abstract 32. Presented at: ACG; Oct. 16-21, 2015; Honolulu.
Disclosures: The researchers report no relevant financial disclosures.