This article is more than 5 years old. Information may no longer be current.
Survivors of AYA bone, soft tissue sarcoma at risk for long-term mortality
Click Here to Manage Email Alerts
Adolescents and young adults who survive bone and soft tissue sarcoma are at increased risk for long-term mortality due to second malignant neoplasms and all causes compared with the general population, according to results of a population-based study.
Researchers evaluated SEER data from 28,844 patients adolescent and young adult (AYA) patients aged 15 years to 39 years. The analysis included 113,206 person-years of follow-up.
All-cause mortality occurred in significantly more AYA sarcoma survivors compared with the general population (standardized mortality ratio [SMR]=1.76; 95% CI, 1.60-1.92). The increased risk for death was apparent for more than 20 years (SMR=1.39; 95% CI, 1.04-1.82).
Increased mortality among AYA sarcoma survivors was associated with second malignant neoplasms (SMR=2.05; 95% CI, 1.71-2.43) and non-cancer causes (SMR=1.66; 95% CI, 1.49-1.85).
AYA sarcoma survivors with chemotherapy-sensitive disease demonstrated a higher mortality risk than those with non-chemotherapy–sensitive disease, although researchers noted both these subtypes experienced excess mortality compared with the general population (SMR=2.76; 95% CI, 2.20-3.41 for chemotherapy-sensitive disease vs. SMR=1.63; 95% CI, 1.47-1.80 for non-chemotherapy–sensitive disease).
Non-cancer related mortality was common among survivors with chemotherapy-sensitive disease due cardiovascular disease (SMR=2.33) and infections (SMR=15.6). Patients with non-chemotherapy–sensitive disease were at risk for death from diabetes (SMR=2.40) as well as infections (SMR=2.77).
“Increases in mortality appear to be more pronounced in patients with sarcomas that require aggressive treatment,” the researchers concluded. “The results of the current study further emphasize the importance of vigilant screening for secondary malignant neoplasms and other late effects in this young population, as well as the future conduct of analytic studies to further understand underlying mechanisms to develop preventive and interventional strategies.”
Disclosure: The researchers report no relevant financial disclosures.
Click Here to Manage Email Alerts