This article is more than 5 years old. Information may no longer be current.
Stereotactic radiosurgery controlled CNS metastases in renal cell carcinoma
Stereotactic radiosurgery achieved excellent local control in patients with central nervous system metastases from renal cell carcinoma, according to results of a retrospective study.
The study included 166 patients with renal cell carcinoma who had CNS metastases. All patients underwent stereotactic radiosurgery at Cleveland Clinic between 1996 and 2010. Follow-up was 1 month to 2 months after radiosurgery, then every 3 months to 6 months after.
Ninety percent of patients achieved local control; of them, 38% developed additional distant CNS metastases at a median of 12.8 months (95% CI, 8.5-21.1). Median time to local or distant progression was approximately 9.9 months (95% CI, 5.9-12.9).
Higher renal cell carcinoma-specific graded prognostic assessment score was the only factor identified as a significant prognostic factor for improved outcome (P=.02), although the findings suggest presence of a single target lesion (P=.07) and age ≥60 years (P=.07) may be associated with better CNS control.
“Stereotactic radiosurgery for a limited number of CNS metastases from renal cell carcinoma is associated with excellent local control and is an effective if not preferred treatment modality,” the researchers concluded.
Disclosure: See the study for a full list of the researchers’ relevant financial disclosures.