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Researchers from Japan recently confirmed that using carbon ion radiotherapy is effective in controlling cancer growth in patients with spinal sarcomas, according to a study published in Cancer.
“This report is the first one regarding spinal sarcomas treated with carbon ion radiotherapy, and our findings offer a treatment alternative to patients with inoperable tumors,” Reiko Imai, MD, PhD, of the Research Center Hospital for Charged Particle Therapy at the National Institute of Radiological Sciences in Japan, stated in a press release.
Imai and colleagues studied 47 patients with 48 nonoperable spinal sarcomas between 1996 and 2011. The patients received doses of carbon ion radiotherapy (CIRT) that ranged from 52.8 GyE and 70.4 GyE in 16 fixed fractions over a 4-week period, according to the abstract.
The median follow-up was 25 months, and the patients’ median survival was 44 months. Overall, 5-year survivorship for patients was 52%, local control was 72% and progression-free rates were 48%. Of the surviving 28 patients, 22 patients with primary tumors were able to walk without support.
There were no fatal toxicities at follow-up and Imai and colleagues reported no patients who had a sarcoma measuring <100cm3 had a local recurrence. However, seven patients had vertebral body compression and one patient had a grade 3 late spinal resection. One patient also had a late grade 3 skin reaction and a late grade 4 skin reaction.
Reference:
Matsumoto K. Cancer. 2013;doi:10.1002/cncr.28177. Disclosure: The authors have no relevant financial disclosures.
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