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L1CAM may predict outcomes in endometrial cancers
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Immunohistochemical L1CAM served as a strong predictive factor for recurrence and survival in a cohort of individuals with endometrial cancers, study results showed.
Fédération Internationale de Gynécologie et d'Obstétrique (FIGO) stage 1, type I endometrial cancers have an excellent prognosis but often result in recurrence and death, according to background information provided by researchers.
The current retrospective cohort study served as an investigation of immunohistochemical L1CAM determination as a predictor of outcomes in this patient population.
The analysis included 1,021 endometrial cancer samples, of which 17.7% were positive for L1CAM. The recurrence rate among the L1CAM-positive cancers was 51.4%, compared with 2.9% among the negative samples.
Disease-free survival and OS were poorer in L1CAM-positive patients than in L1CAM-negative patients (P<.001).
Multivariate analysis results indicated that L1CAM positivity was associated with an increased chance for recurrence (HR=16.33; 95% CI, 10.55-25.28) and death (HR=15.01; 95% CI, 9.28-24.26).
Grade and risk assessment failed to predict survival outcomes in the L1CAM-negative, FIGO stage I cohort. L1CAM positivity was the only prognostic factor among the parameters evaluated.
L1CAM carried a sensitivity of 0.74 and a specificity of 0.91 in predicting recurrence, according to results of a classification and regression decision tree analysis. Results of this same analysis indicated that L1CAM also predicted mortality (sensitivity=0.77; specificity=0.89).
“L1CAM expression in type I cancers indicates the need for adjuvant treatment,” the researchers concluded. “This adhesion molecule might serve as a treatment target for the fully humanized anti-L1CAM antibody currently under development for clinical use.”
Disclosure: The researchers report no relevant financial disclosures.
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