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Vitamin D receptor gene linked to risk for melanoma

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An association has been found between the vitamin D receptor gene polymorphism BsmI and the risk for melanoma.

Researchers from the University of Padova in Italy conducted a meta-analysis of the results of six studies that examined the association between five vitamin D receptor polymorphisms — Taql, Fokl, BsmI, EcoRV and CDX2 — and the risk for developing melanoma.

They found a significant association between the BsmI vitamin D receptor polymorphism and melanoma risk (OR=1.30; 95% CI, 1.11-1.53); the population-attributable risk was 9.2%, according to the researchers.

The OR for the Fokl polymorphism was 1.09 (95% CI, 0.99-1.21). Significant between-study heterogeneity did not support genotype data pooling for the Taql and EcoRV polymorphisms, according to the researchers. The only study that examined the CDX2 polymorphism demonstrated negative findings.

“The current findings prompt further investigation on this subject and indirectly support the hypothesis that sun exposure may have an antimelanoma effect through activation of the vitamin D system,” the researchers wrote.

Cancer. 2008;doi:10.1002/cncr.23867.