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Bloodstream infections increased risk for colorectal cancer
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2011 ICAAC
CHICAGO — Patients who develop incident bloodstream infections are at increased risk for diagnosis of colorectal cancer within 1 year of infection, according to data presented here.
Bloodstream infections may be a marker for colorectal malignancy. Therefore, researchers set out to determine the overall and species-specific risk for colorectal cancer within 1 year after incident infection.
Between 2000 and 2007, researchers conducted a population-based inception cohort design in adults in the Calgary Health Zone (n=1.2 million). Those with bloodstream infections were followed until development of colorectal cancer or mortality through 2008.
A total of 10,121 bloodstream infections occurred among 8,806 patients with a mean age of 62.4 years; 54.5% were male.
Colorectal cancer was diagnosed in 3,859 regional residents, of which 349 occurred after an incident bloodstream infection. Compared with the general population, 71 patients had colorectal cancer diagnosed concomitantly with or within 1 year after infection (95% CI, 11.3-18.3).
Clostridium, Bacteroides fragilis and other anaerobes were significant risk factors for a new colorectal diagnosis, according to the researchers. In addition, male gender, age, a higher Charlson comorbidity score and liver disease were significant risk factors.
The researchers recommend "further research to define the role of colorectal cancer preventive or early diagnostic screening investigations in patients who present with bloodstream infections."
For more information:
- Warren SJC. #K-834. Presented at: the 2011 ICAAC; Sept. 17-20; Chicago.
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