Anti-redness regimen improves rosacea, maintains excellent tolerability

Key takeaways:

• Overall facial erythema improved by 21% at week 4 and 32% at week 8.
• Improvements in other subcategories including tactile roughness, visual roughness and radiance and brightness also exceeded 20%.

An anti-redness regimen comprised of a redness reducing serum, moisturizer and sunscreen improved the signs and symptoms of rosacea while maintaining excellent tolerability, according to a study.

“Rosacea is a multifactorial condition that involves a complex interaction between genetics, immune system dysregulation, microorganisms, UV light, neurovascular dysregulation and impaired barrier function,” Patricia K. Farris, MD, clinical associate professor of dermatology at Tulane University School of Medicine, and colleagues wrote. “Given [the] complex pathogenesis, treatment of rosacea requires a multimodal approach.”

In this study, the authors investigated the efficacy and tolerability of a daily anti-redness regimen comprised of a redness reducing serum (AlumierMD Calm-R), a treatment moisturizer (AlumierMD HydraCalm) and a sunscreen (AlumierMD Clear Shield Broad Spectrum SPF 42).

Thirty patients aged 35 to 65 years with Fitzpatrick skin types I and II and rosacea-induced facial erythema were instructed to use their own facial cleanser along with the anti-redness regimen in the morning and at night, excluding the sunscreen at night.

Results showed that overall facial erythema improved by 21% at week 4 (P = .001) and 32% at week 8 (P < .001), according to investigators.

Radiance and brightness, tactile roughness and visual roughness also improved by 25%, 34% and 29%, respectively, at week 4 and progressively improved to 37%, 44% and 41% by week 8 (P < .001 for all). A 15% reduction in fine lines was also observed by the investigators at week 8 (P = .004).

The anti-redness regimen garnered enthusiasm from participants, with subjects reporting marked improvements in facial erythema (39%; P < .001), fine lines (21%; P = .002), wrinkles (23%; P < .001), radiance and brightness (44%; P < .001), tactile roughness (47% P < .001), visual roughness (52%; P < .001) and overall appearance (40%; P < .001).

According to the investigators, the regimen was excellently tolerated while subjects noted an increase in dryness at week 4 (P = .004) and week 8 (P = .005).

The study reports that key ingredients contributed to the success of this regimen including piperonyl glucoside, hinokitiol, Poria cocos, aloe vera, sunflower seed oil, niacinamide, copper tripeptide 1, Pinus cembra and a combination of tetrapeptide-14, tea extracts, Boswellia serrate extract and honey.

The investigator did not identify any tolerability issues with dryness, peeling, erythema or edema, and overall tolerability was deemed excellent.

“Cosmetics are playing a greater role in the treatment of inflammatory skin disorders such as rosacea,” the authors wrote. “The data presented here support the use of this carefully formulated skincare regimen for improving facial redness due to rosacea.”