Abdominal skin aging reduced with carboxytherapy
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Key takeaways:
- In this split body study, skin treated with carboxytherapy had increased thickness, collagen and elastin scores.
- Epidermal and lymphatic TGF-B1, as well as VEGF, all also showed significantly higher scores.
Abdominal skin treated with carboxytherapy showed a significant increase in epidermal and dermal thickness, according to a study.
“Aging as a continuous and irreversible process affecting the skin is clinically characterized by skin laxity, wrinkling, fragility, xerosis and pruritus, increased sensitivity to temperature, impaired wound healing and increased risk of malignancies,” Nooshin Bagherani, MD, MA, PhD, of the department of molecular medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, and colleagues wrote. “This process, which mainly is the result of alterations of function and structure of the dermis, is characterized by thinning, decreased hydration and loss of elasticity.”
Carboxytherapy, a process in which intradermal and/or subcutaneous microinjections of carbon dioxide are administered to different parts of the body, has been used for dermatologic and cosmetic indications.
A prospective, split-body study included 15 women (average age, 44.43 years; age range, 40-56.5 years) who had visible aging of the abdominal skin.
Each subject received weekly carboxytherapy sessions on one side of their body using Medaion (Nik Fanavaran Plasma Co.), a digitally controlled carboxytherapy device, for 10 weeks.
The other side of the body was left untreated.
Skin samples were taken and tested from both sides 2 weeks after the last session, evaluating pathological and immunohistochemical (IHC) results, including transforming growth factor-beta1 (TGF-B1) and vascular endothelial growth factor (VEGF) investigations.
Mean epidermal thickness was 0.25 ± 0.06 mm in the treatment group and 0.14 ± 0.02 mm in the control group and the mean dermal thickness was 3.2 ± 1.02 mm in the treatment group and 1.5 ± 0.8 mm in the control group. A statistically significant increase in thickness was measured in the treatment group based on the paired t-test (P < .001).
Collagen and elastin scores were significantly increased in the treatment groups, measured by NPar Wilcoxon Signed Ranks Tests.
Epidermal and lymphatic TGF-B1, as well as VEGF, all also showed significantly higher scores in the treatment group compared with the control samples (P = .001 for both).
“In our study, assessment of hematoxylin-eosin-stained slides revealed the statistically significant effect of carboxytherapy in increasing the thickness of the epidermis and dermis,” the authors wrote.
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