Brightening serum plus antioxidant improves hyperpigmentation in patients with skin of color

Facial hyperpigmentation was improved in patients with skin of color who used a cosmetic topical brightener combined with a dual serum antioxidant system, according to a poster presented at the Skin of Color Update virtual meeting.

“Hyperpigmentation disorders disproportionately affect individuals with skin of color,” Seemal R. Desai, MD, of the department of dermatology at the University of Texas Southwestern Medical Center, and colleagues wrote.

“Comprehensive treatment regimens are needed to adequately address hyperpigmentation in skin of color.”

An open-label, single center study included 13 patients (mean age, 44; 92% female), of which 10 completed the study.

All participants were Asian, Hispanic or African American and they each had investigator-assessed moderate to severe overall facial hyperpigmentation.

Each patient received a treatment regimen that included a dual serum antioxidant system (LVS), a cosmetic topical brightener (LYT2), a facial cleanser, a broad-spectrum SPF 35 sunscreen and an ultra-sheer moisturizer, all to be used twice daily.

After 4 weeks of treatment significant changes in skin-tone evenness and radiance were reported, and at week 12 all investigator efficacy assessment parameters had significant improvement. These included overall hyperpigmentation, skin-tone evenness and radiance.

Patient-reported efficacy was also reported by all patients at week 12, with most patients reporting good or excellent overall satisfaction.

“The LYT2 + LVS may be a novel, non-prescription regimen for skin of color patients seeking to improve hyperpigmentation and overall skin quality,” the authors wrote.