
Society for Cardiovascular Angiography and Interventions
Lessons learned from new trials of prasugrel in patients with ACS

SAN DIEGO — Efficacy is established in randomized clinical trials. Effectiveness, however, is established in registry and/or nonrandomized observational data. The PROMETHEUS and TRIAGE studies, both presented as late-breaking clinical trials at the Society for Cardiovascular Angiography and Interventions Scientific Sessions, were attempts to establish effectiveness of prasugrel (Effient, Daiichi Sankyo/Eli Lilly).
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TRIAGE: Risk algorithm identifies patients who may benefit from intensive antiplatelet therapy
An in-depth look at the ORBIT II trial
MILLION: Combined BP, cholesterol lowering reduces coronary plaque volume

SAN DIEGO — Among patients with CAD, an aggressive or standard approach of combined BP and cholesterol lowering after successful PCI resulted in similar reductions in coronary plaque volume, according to results of the MILLION study presented at the Society for Cardiovascular Angiography and Interventions Scientific Sessions.
Clinical profile of ACS patients treated with prasugrel, clopidogrel varies in US
IABP may improve mortality among patients with cardiogenic shock unable to undergo timely PCI
SAN DIEGO — Patients with cardiogenic shock after STEMI who were unable to receive timely PCI had a better rate of in-hospital mortality when treated with an intra-aortic balloon pump compared with no mechanical circulatory support, according to data presented at the Society for Cardiovascular Angiography and Interventions Scientific Sessions.
The new frontier: Interventional cardiology and technology
Ticagrelor more effective than clopidogrel for ad-hoc PCI

SAN DIEGO — Troponin-negative patients with ACS undergoing ad-hoc PCI had greater, more rapid reductions in platelet reactivity after treatment with ticagrelor compared with clopidogrel, according to results of a pharmacodynamics study presented at the Society for Cardiovascular Angiography and Interventions Scientific Sessions.
ORBIT II: Atherectomy system associated with durable long-term results, potential cost savings

SAN DIEGO — Use of an orbital atherectomy system to remove severely calcified plaque in the coronary arteries prior to stent placement resulted in low rates of major adverse cardiac events at 2 years, according to results of the ORBIT II trial presented at the Society for Cardiovascular Angiography and Interventions Scientific Sessions.