Inflammatory bowel disease linked to ASCVD, especially in younger adults
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Adults with inflammatory bowel disease were more likely to have atherosclerotic CVD than those without it, according to study findings published in the American Journal of Preventive Cardiology.
The relationship was strongest in adults aged 18 to 44 years and not significant in those aged 65 years or older.
Khurram Nasir, MD, MPH, MSc, chief of cardiovascular prevention and wellness at Houston Methodist DeBakey Heart and Vascular Center and co-director of the Center for Outcomes Research at Houston Methodist, and colleagues conducted a cross-sectional analysis of 66,610 participants from the 2015-2016 National Health Interview Survey to assess the relationship between inflammatory bowel disease (IBD) and ASCVD.
Among the cohort, 1.3% (95% CI, 1.2-1.4) reported having IBD. Those with IBD were older, more likely to be women and more likely to be white than those without it.
The age-adjusted prevalence of ASCVD was 12% in those with IBD (95% CI, 9.7-14.2) and 6.9% in those without it (95% CI, 6.6-7.1; P < .001), Nasir and colleagues wrote.
In multivariable regression analyses, even after adjustment for demographics and traditional risk factors, having IBD was associated with elevated odds of ASCVD (adjusted OR = 1.58; 95% CI, 1.17-2.13), according to the researchers.
The relationship between IBD and ASCVD varied by age (P for interaction < .001), with the strongest association occurring in adults aged 18 to 44 years (aOR = 3.35; 95% CI, 1.75-6.4) and no association occurring in adults aged 65 years or older.
The results did not vary by sex, the researchers wrote.
“Mechanistic and interventional studies are needed to confirm a causal association between IBD and ASCVD and identify opportunities to enhance ASCVD prevention in young and middle-aged adults with IBD,” Nasir and colleagues wrote.
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